Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study.
نویسندگان
چکیده
BACKGROUND Limited information is available on the association between vitamin B-12 status and intake from different dietary sources. OBJECTIVE We investigated the relation of dietary intake of different food items with plasma vitamin B-12 concentrations in the general population. DESIGN A cross-sectional, population-based study of 5937 subjects in 2 age groups (47-49 and 71-74 y) from the Hordaland Homocysteine Study in Norway was conducted by using a food-frequency questionnaire and measurements of plasma vitamin B-12 concentrations. RESULTS A significant difference in plasma vitamin B-12 concentrations was observed with increasing total vitamin B-12 intake. A plateau was reached at an intake of approximately 10 microg/d. Plasma vitamin B-12 was associated with intakes of increasing amounts of vitamin B-12 from dairy products or fish (P for trend <0.001 for both) but not with intakes of vitamin B-12 from meat or eggs. For the same content of vitamin B-12, intake from dairy products led to the greatest increase in plasma vitamin B-12. Total intake of vitamin B-12, particularly from milk and fish, decreased the risk of vitamin B-12 concentrations <200 pmol/L and impaired vitamin B-12 function (vitamin B-12 <200 pmol/L and methylmalonic acid >0.27 micromol/L) in the total group and in 71-74-y-old subjects. CONCLUSIONS Dietary intake of dairy products and fish are significant contributors to plasma vitamin B-12 and may improve plasma vitamin B-12 status. Vitamin B-12 appears to be more bioavailable from dairy products; guidelines for improving vitamin B-12 status should take this into consideration.
منابع مشابه
Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status.
BACKGROUND Methylmalonic acid (MMA) in plasma or serum is widely used for assessment of vitamin B(12) status. However, data are sparse regarding factors, besides renal function, that may influence MMA concentrations. We searched for important determinants of plasma MMA in the general population. METHODS In 6946 middle-aged (47-49 years) and elderly (71-74 years) individuals from the Hordaland...
متن کاملAssociation between B vitamin intake and plasma homocysteine concentration in the general Dutch population aged 20-65 y.
BACKGROUND An elevated plasma total homocysteine (tHcy) concentration is associated with an increased risk of cardiovascular diseases. Folate, riboflavin, vitamin B-6, and vitamin B-12 are essential in homocysteine metabolism. OBJECTIVE The objective was to describe the association between dietary intakes of folate, riboflavin, vitamin B-6, and vitamin B-12 and the nonfasting plasma tHcy conc...
متن کاملStudy of plasma homocysteine, folic acid and vitamin B-12 levels for radiation exposed transplanted solid Ehirlich tumors
Background: Alterations of systemic metabolic parameters are always present vitamins in cancer in addition radiotherapy may increases and complicates these disorders. The analysis of each biochemical metabolic alterations may give more understanding to biochemistry of malignancy and improving the degree of radiotherapy. The current study aimed to follow up the changes of folate, vitamin B12 a...
متن کاملHigh homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study.
BACKGROUND Elevated homocysteine concentrations may contribute to cognitive impairment. Most elevations in homocysteine result from inadequate folate, vitamin B-12, or vitamin B-6 intake. It is not clear whether the observed associations between homocysteine and cognitive measures are causal or whether they are due to homocysteine, to independent actions of the B vitamins, or to both. OBJECTI...
متن کاملDietary fat and plasma total homocysteine concentrations in 2 adult age groups: the Hordaland Homocysteine Study.
BACKGROUND The intake of n-3 (formerly called omega-3) fatty acids (FAs) may be inversely associated with plasma total homocysteine (tHcy) concentrations, but the epidemiologic data are sparse. OBJECTIVE We examined the association between dietary fat and tHcy in a Norwegian population. DESIGN A cross-sectional, population-based study of 5917 subjects in 2 age groups (47-49 and 71-74 y old)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The American journal of clinical nutrition
دوره 89 4 شماره
صفحات -
تاریخ انتشار 2009